The analog switch-off in a cable dominated television landscape. Implications for the transition to digital television in Flanders

Flanders will complete the migration from analog to digital terrestrial television by the end of 2008. Despite the cable dominated television landscape, the Flemish government is aiming at a smooth transition from analog to digital terrestrial television. Therefore, a multi-methodical study (quantitative survey and qualitative focus group interviews) has been set up by order of the Flemish government to understand the specific features and needs of analog antenna viewers and their expectations for the analog switch-off. The study shows that there are three distinctive types of analog antenna viewers. The results demonstrate that the antenna viewers are rather badly informed about the upcoming analog switch-off, which may lead to a negative attitude and may impede a smooth transition. Finally, antenna viewers seem to be rather conservative viewers: they wish to keep on watching the same television programs from the same channels. Moreover, digital terrestrial television is their preferred alternative

The composition and role of convergent technological repertoires in audiovisual media consumption

This mixed-method research focuses on the growing appropriation of multiple screen devices for audiovisual media consumption. Based on survey measures, we distinguish three patterns: (a) maintaining the status quo, by mainly drawing upon television, (b) broadening up the repertoire, by extending television with computers and mobile devices, or (c) even replacing television by a computer. Next, we draw upon insights from niche theory, rationalising media choices in terms of competing gratifications. This perspective is however too one-sided, as our results indicate that habit is a much stronger explanatory variable, especially when a broad range of devices are appropriated. In a follow-up qualitative study, based on Q-methodology, we found that the orientations towards what people seek in audiovisual technologies are only mildly contingent with specific technology appropriation. This problematises the very substance of niches in the audiovisual: as technologies are capable of the same benefits, their discriminating power is declining. Hence, in future applications of niche theory, gratifications and habits of communication modes (what people do with media technologies) should be taken into account, rather than media as tied to a specific technology. Niche theory's core remains, but its applications should be updated to theoretical insights matching the evolving media environment

Identification of New Alleles and the Determination of Alleles and Genotypes Frequencies at the CYP2D6 Gene in Emiratis

CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20–25% of clinically used drugs including antidepressants. It displays inter-individual and inter-ethnic variability in activity ranging from complete absence to excessive activity which causes adverse drug reactions and toxicity or therapy failure even at normal drug doses. This variability is due to genetic polymorphisms which form poor, intermediate, extensive or ultrarapid metaboliser phenotypes. This study aimed to determine CYP2D6 alleles and their frequencies in the United Arab Emirates (UAE) local population. CYP2D6 alleles and genotypes were determined by direct DNA sequencing in 151 Emiratis with the majority being psychiatric patients on antidepressants. Several new alleles have been identified and in total we identified seventeen alleles and 49 genotypes. CYP2D6*1 (wild type) and CYP2D6*2 alleles (extensive metaboliser phenotype) were found with frequencies of 39.1% and 12.2%, respectively. CYP2D6*41 (intermediate metaboliser) occurred in 15.2%. Homozygous CYP2D6*4 allele (poor metaboliser) was found with a frequency of 2% while homozygous and heterozygous CYP2D6*4 occurred with a frequency of 9%. CYP2D6*2xn, caused by gene duplication (ultrarapid metaboliser) had a frequency of 4.3%. CYP2D6 gene duplication/multiduplication occurred in 16% but only 11.2% who carried more than 2 active functional alleles were considered ultrarapid metabolisers. CYP2D6 gene deletion in one copy occurred in 7.5% of the study group. In conclusion, CYP2D6 gene locus is heterogeneous in the UAE national population and no significant differences have been identified between the psychiatric patients and controls

Methyl methacrylate and respiratory sensitization: A Critical review

Methyl methacrylate (MMA) is a respiratory irritant and dermal sensitizer that has been associated with occupational asthma in a small number of case reports. Those reports have raised concern that it might be a respiratory sensitizer. To better understand that possibility, we reviewed the in silico, in chemico, in vitro, and in vivo toxicology literature, and also epidemiologic and occupational medicine reports related to the respiratory effects of MMA. Numerous in silico and in chemico studies indicate that MMA is unlikely to be a respiratory sensitizer. The few in vitro studies suggest that MMA has generally weak effects. In vivo studies have documented contact skin sensitization, nonspecific cytotoxicity, and weakly positive responses on local lymph node assay; guinea pig and mouse inhalation sensitization tests have not been performed. Cohort and cross-sectional worker studies reported irritation of eyes, nose, and upper respiratory tract associated with short-term peaks exposures, but little evidence for respiratory sensitization or asthma. Nineteen case reports described asthma, laryngitis, or hypersensitivity pneumonitis in MMA-exposed workers; however, exposures were either not well described or involved mixtures containing more reactive respiratory sensitizers and irritants.The weight of evidence, both experimental and observational, argues that MMA is not a respiratory sensitizer

Rethinking determinants of ICT acceptance : Towards an integrated and comprehensive overview

In the contemporary ICT environment, we are confronted with a growing number of failing innovations.New technological innovations often fail because too much attention is still given to (technical)product-related features without taking into account the most important parameters of useracceptance. In addition, suppliers of ICT products often lack accurate insight into the distinguishedprofiles of their (potential) target audience. In this article theoretical considerations and empiricalresults on this matter are highlighted. First of all, an approach is proposed in which more traditionaland often scattered vision(s) on adoption determinants are broadened into an integrated framework.The approach provides a stronger base for better targeting of (new) users of technologies. Secondly, theauthors elaborate on this by rethinking these determinants with regard to later adopters. Later adopters(or even non-adopters/users) are often ignored in technology acceptance research. However, especiallyfor policy purposes, the understanding of why people do not adopt or do not use ICT is strongly relevantin the light of the development of an inclusive information society. Both approaches are illustrated bycase studies starting from a common list of nineteen ICT appropriation determinants. This frameworkenables to better profile both earlier and later adopters as well as it allows to formulate recommendationshow to bring innovations in the market. Summarizing, this contribution offers an integratedapproach on technology acceptance research by bridging the gap between a market and a policyorientedpoint of view